Evaluation of antioxidant-oxidant status of saliva in recurrent aphthous stomatitis: A systematic review

BACKGROUND AND AIM: Recurrent Aphthous Stomatitis (RAS) as a common oral lesion can be related to oxidative stress. The aim of this study was to review the antioxidant-oxidant status of saliva in patients with RAS.METHODS: In this review study, all English and Persian articles were searched by relevant keywords from the PubMed, science direct, Cochrane, Scopus and Sid databases from 1995 to 30 March 2020. Two independent reviewers performed the study selection using specified eligibility criteria. Finally, Newcastle-Ottawa Scale method has been used for the quality evaluation of studies.RESULTS: A systematic search of sources identified 87 articles, of which 68 were excluded and finally, 19 articles were included in the study. The majority of studies (86%) showed no significant decrease in total antioxidant capacity. In 71% of studies the malondialdehyde levels exhibited an increasing trend and in all studies glutathion peroxidase had decreasing trend; the results in relation to uric acid were contradictory. CONCLUSION: Beyond the need for more extensive research in this area, it can be concluded that since RAS have multifactorial etiology, changes in the body's antioxidant-oxidant status are considered as an effective factor along with other factors.